Cerebrospinal Fluid Pulsation Bioreactor

Name: Cerebrospinal Fluid Pulsation Bioreactor
Brand: Baiqiao Medical

The cerebrospinal fluid pulsation bioreactor reproduces a pulsatile biomechanical environment for dynamic in vitro culture of cell–biomaterial constructs and records experimental data in real time.

It supports the engineering of living bone tissue with biomechanical properties, biocompatibility, and biological activity relevant to bone-tissue research and applications.

Model:BQ-4800

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+86-0571-85236562(Currently available in Chinese only)

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Product Specifications

Application Areas	Healthcare, environmental protection, biotechnology, pharmaceuticals and biopharmaceuticals, general applications

Product Overview

The cerebrospinal fluid pulsation bioreactor reproduces a pulsatile biomechanical environment for dynamic in vitro culture of cell–biomaterial constructs and records experimental data in real time.

It supports the engineering of living bone tissue with biomechanical properties, biocompatibility, and biological activity relevant to bone-tissue research and applications.

Cerebrospinal Fluid Pulsation Bioreactor

1. Intended Applications:

For in vitro engineering of bioactive bone tissue and research on cell–biomaterial compatibility, fatigue properties, and toxicity.

Suitable for product development and scientific experiments at universities, hospitals, research institutes, biological laboratories, and biomaterials research organizations.

2. Main Functions and Features:

(1) Simulates the cerebrospinal fluid hydrodynamic environment of animals and humans.
(2) Modular design allows each unit to operate independently.
(3) An accompanying hydrodynamic test device can be provided for checking and calibrating the force generated by the pulsation actuator.
(4) The pulsation actuator has a suitable elastic modulus, good mechanical transmission, no cytotoxicity, and good biocompatibility.
(5) Each culture unit contains two scaffold holders for an experimental group and a blank control. Units can be assembled, removed, or repositioned as needed and placed in an incubator at 5% CO₂ and 37 °C. Scaffold handling and medium changes are convenient and designed to reduce contamination risks.
(6) Each dynamic culture unit is enclosed and maintains suitable pH and carbon-dioxide levels. The effect of medium-flow-induced shear on cells attached to the scaffold is negligible.

Cerebrospinal Fluid Pulsation Bioreactor

3. Technical Specifications:

(1) Pulsatile pressure range: 0–250 mmHg.
(2) Frequency: 0–250 cycles/min.
(3) Inner diameter of cerebrospinal-fluid simulation tubing: Ø6–Ø10 mm.
(4) Number of culture units: 1–6.
(5) Temperature-control range: 5–60 °C.
(6) Compliance: 0–5%.
(7) pH-control range: 0–14.
(8) CO₂-control range: 0–20%.
(9) Power supply: 220 V AC ±10% / 50 Hz ±2%.
(10) Output power: 200 W.

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