1. Regulates mechanosignaling pathways through mechanical stimulation to maintain stem-cell
self-renewal and inhibit differentiation.
2. Avoids introducing microcarriers, reducing the risks associated with returning stem cells
to the body.
3. Produces cleaner cell supernatant, providing favorable conditions for subsequent exosome
purity.
4. Mechanical stimulation can promote and increase stem-cell exosome yield.
5. Mechanical stimulation can regulate exosome composition and function.

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